Prenatal diagnosis of arachnoid cysts: MRI features and neurodevelopmental outcome. Issue 113 (April 2019)

• Record Type: Journal Article
• Authors: Yahal, Orr; Katorza, Eldad; Zvi, Elad; Berkenstadt, Michal; Hoffman, Chen; Achiron, Reuven; Bar-Yosef, Omer
• Is Part Of: European journal of radiology. Issue 113(2019)
• Page Start: 232
• Page End: 237
• Publication Date: 2019-04
• Subjects: AC arachnoid cyst -- CSF cerebrospinal fluid -- US ultrasound -- MRI magnetic resonance imaging -- CNS central nervous system -- VABS Vineland II Adaptive Behavior Scale -- TOP termination of pregnancy -- VSD ventricular septal defect -- FOV field of view; Fetal brain -- MRI -- Arachnoid cyst -- Supratentorial cyst -- Infratentorial cyst -- Neurodevelopmental outcome; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2019.02.027
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: Arachnoid cyst are intracranial congenital lesions, can be demonstrated by prenatal MRI. The neurodevelopmental outcome of the fetuses diagnosed with arachnoid cyst is variable. In our cohort 17/22 (77.3%) of the fetuses diagnosed prenatally with arachnoid cyst had normal neurodevelopmental outcome. In our cohort 2/22 (9.1%) of the fetuses diagnosed prenatally with arachnoid cyst underwent surgical intervention for expanding arachnoid cyst. Abstract: Objective: Arachnoid cysts (AC) are congenital lesions comprising 1% of all intracranial mass lesions. The aim of this study was to characterize arachnoid cysts and their neurodevelopmental outcome and to compare it with the outcome of children without AC. Methods: This is a retrospective cohort study of arachnoid cysts detected prenatally by fetal MRI in 29 fetuses compared to a control group of 59 fetuses without arachnoid cyst who were examined by MRI. The cohort was investigated from two different angles: anatomical and developmental. Anatomical analyzation, the cohort was divided into 2 groups by the arachnoid cyst anatomical location: group A (n = 9), which included cases with supratentorial cyst, and group B (n = 20), which included cases with infratentorial cyst. Developmental analyzation, the cohort was divided into 2 groups by the neurodevelopmental outcome: group γ (n = 5) which included cases that were affected by arachnoid cyst presence, and group δ (n = 17) which included cases that had neurodevelopmental outcome within the normal range. Data collected included prenatal history, MRI features, sonographic follow up, and neurodevelopmental outcome. Results: In 22/29 cases we achieved a long-term follow up, by evaluation of children development in a range of ages from 6 months to 6 years. In group A (n = 9), 4 infants had normal outcome, 2 had abnormal outcome, 1 pregnancy was terminated, and 2 cases were not cooperative with the study. In group B (n = 20), 13 infants had normal outcome, 3 had abnormal outcome, and 4 cases were not cooperative with the study. Conclusions: From all cases with AC detected by fetal MRI, 77.3% had normal neurodevelopmental outcome and 22.7% had abnormal neurodevelopment.