Zebrafish models for attention deficit hyperactivity disorder (ADHD). (May 2019)

• Record Type: Journal Article
• Authors: Fontana, Barbara D.; Franscescon, Francini; Rosemberg, Denis B.; Norton, William H.J.; Kalueff, Allan V.; Parker, Matthew O.
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 100(2019)
• Page Start: 9
• Page End: 18
• Publication Date: 2019-05
• Subjects: ADHD -- Zebrafish -- Behavior -- Genetics -- Dopamine -- Noradrenaline -- Serotonin; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2019.02.009
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: ADHD is a neurodevelopmental disorder that affects an increasing number of people worldwide. Zebrafish is a prominent model to assess the underlying mechanisms of ADHD and it comorbidities. Advantages and disadvantages of using zebrafish to model ADHD were discussed. Current zebrafish ADHD models and future directions are highlighted. Abstract: Attention deficit hyperactivity disorder (ADHD) is a common, debilitating neurodevelopmental disorder associated with inattentiveness, pathological hyperactivity and impulsivity. Despite the mounting human and animal evidence, the neurological pathways underlying ADHD remain poorly understood. Novel translational model organisms, such as the zebrafish ( Danio rerio ), are becoming important tools to investigate genetic and pathophysiological mechanisms of various neuropsychiatric disorders. Here, we discuss ADHD etiology, existing animal models and their limitations, and emphasize the advantages of using zebrafish to model ADHD. Overall, the growing utility of zebrafish models may improve our understanding of ADHD and facilitate drug discovery to prevent or treat this disorder.