Nanocomposite sponges of sodium alginate/graphene oxide/polyvinyl alcohol as potential wound dressing: In vitro and in vivo evaluation. (15th June 2019)

• Record Type: Journal Article
• Authors: Ma, Rongxiu; Wang, Yajing; Qi, Houjuan; Shi, Cai; Wei, Guangbiao; Xiao, Lidong; Huang, Zhanhua; Liu, Shouxin; Yu, Haipeng; Teng, Chunbo; Liu, Hu; Murugadoss, Vignesh; Zhang, Jiaoxia; Wang, Yonggui; Guo, Zhanhu
• Is Part Of: Composites. Number 167(2019)
• Page Start: 396
• Page End: 405
• Publication Date: 2019-06-15
• Subjects: Nanocomposite sponges -- Cell proliferation -- Antibacterial activity -- Wound healing; Composite materials -- Periodicals; Materials science -- Periodicals; Composite materials; Periodicals; Electronic journals; 620.118
• DOI: 10.1016/j.compositesb.2019.03.006
• Languages: English
• ISSNs: 1359-8368

Abstract

Abstract: Wound dressings with high flexibility, mechanical strength, and porosity have received increasing attention. Herein, nanocomposite sponges of sodium alginate/graphene oxide (GO)/polyvinyl alcohol were prepared by a freeze-thawing cyclic process and freeze-dried molding. The properties of the sponges were investigated including morphology, mechanical properties, swelling, water vapor permeability, in vitro norfloxacin (NFX) release, antibacterial property, and biocompatibility as well as in vivo wound healing in a mouse model. A GO concentration of 1 wt% resulted in the sponges with a homogeneously porous and interconnected network structure, which exhibited suitable water absorption, breathability, and mechanical properties. Hemolysis tests indicated that the prepared sponges were non-hemolytic material. The CCK-8 assay demonstrated that the presence of an appropriate amount of GO could promote the cell proliferation. The sponges displayed excellent bioavailability of NFX, with a sustained release behavior and a strong inhibitory effect against both Escherichia coli and Staphylococcus aureus . The in vivo evaluations demonstrated that the sponges enhanced wound healing. Therefore, these novel nanocomposite sponges are promising candidates for wound healing applications. Graphical abstract: Image 1 Highlights: The sponges (SPG) were prepared by a freeze-thawing method and freeze-dried technology. The SPG exhibited uniform pore structure and excellent flexibility. Graphene oxide improved biocompatibility of the SPG. The SPG could be used as an excellent wound dressing for biomedical field.