Association between prognosis and SEMA4D/Plexin-B1 expression in various malignancies: A meta-analysis. Issue 7 (February 2019)

• Record Type: Journal Article
• Authors: Yang, Yibo; Wang, Jing; Li, Hui; Liu, Lihong; Yao, Maojin; Xiao, Tao
• Other Names: Efird. Jimmy T. section editor.
• Is Part Of: Medicine. Volume 98:Issue 7(2019)
• Publication Date: 2019-02
• Subjects: malignancy -- meta-analysis -- Plexin-B1 -- prognosis -- SEMA4D; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000013298
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Introduction: SEMA4D and its high affinity receptor Plexin-B1 showed a promising prognosis prediction for carcinoma patients in recent studies, we performed a meta-analysis to evaluate the prognostic role of them in various malignancies. Methods: A systematic literature search was performed in PubMed, Embase, Web of Science, and CNKI from inception till July 2017. Eligible studies were identified by different reviewers. Hazard ratios (HRs)/related ratios (RRs) and their corresponding 95% confidence intervals (CIs) were extracted to investigate the relevance between malignancies prognosis and SEMA4D/Plexin-B1. Results: Around 2638 patients from 14 studies were included in this meta-analysis. High expression of SEMA4D was significantly associated with overall survival (OS) and disease-free survival/progression-free survival/recurrence-free survival (DFS/PFS/RFS) in tumors (respectively, HRos = 2.05, 95%CI: 1.68–2.50, P < .001; HRdfs/pfs/rfs = 1.59, 95%CI = 1.27–1.98, P < .001). However, the relationship between SEMA4D expression and prognosis of breast cancer patients was failed to find (HR = 0.76, 95%CI = 0.32–1.82, P = .539). Plexin-B1 level showed a significant positive correlation both with OS and DFS of Caucasian breast cancer patients (respectively, HRos = 0.56, 95%CI: 0.39–0.79, P = .001; HRdfs = 0.68, 95%CI = 0.51–0.90, P = .008) Conclusions: SEMA4D could be a prospective biomarker for prognostic prediction of various malignancies except breast cancer. For Caucasian breast cancer patients, SEMA4D's high affinity receptor Plexin-B1 showed a significant positive correlation with survival. Abstract : Supplemental Digital Content is available in the text