A feasibility study on 3D interaction position estimation using deep neural network in Cherenkov-based detector: a Monte Carlo simulation study. (12th March 2019)

• Record Type: Journal Article
• Authors: Hashimoto, Fumio; Ote, Kibo; Ota, Ryosuke; Hasegawa, Tomoyuki
• Is Part Of: Biomedical physics & engineering express. Volume 5:Number 3(2019)
• Publication Date: 2019-03-12
• Subjects: positron emission tomography (PET) -- deep learning -- neural network -- interaction estimation -- Cherenkov -- (Cerenkov) radiation; Medical physics -- Periodicals; Biophysics -- Periodicals; Biomedical engineering -- Periodicals; Medical sciences -- Periodicals; 610.153
• DOI: 10.1088/2057-1976/ab098e
• Languages: English
• ISSNs: 2057-1976

Abstract

Abstract: Cherenkov-based radiation detectors have been developed for time-of-flight positron emission tomography. As Cherenkov photons are emitted in an extremely short time, their use can improve time resolution. However, only up to 10 Cherenkov photons are yielded when a 511 keV gamma ray interacts with Cherenkov radiators, such as lead tungstate and lead fluoride (PbF2 ). Therefore, accurate estimation of the interaction position was difficult, and intense effort has been devoted to its improvement. We propose an estimation method for the 3D interaction position using a deep neural network. The network was evaluated by Monte Carlo simulations. For the simulations, a Cherenkov-based detector with a monolithic PbF2 radiator of 40 × 40 × 10 mm 3 and a photodetector array were used. The gamma-ray interaction position in the radiator was estimated in 3D space by the neural network, whose inputs were the detection positions on the photodetector plane ( xy plane) and timestamps of each photon from the detector. Training and validation datasets were generated while varying the single photon time resolution (SPTR) and readout pitch of the photodetector. By comparing several neural network architectures, we determined the best configuration to be the multilayer perceptron with 3 layers and 256 units. The full widths at half maximum of the xy plane and z axis (i.e., depth of interaction) were 1.54 and 1.59 mm with SPTR σ = 10 ps, respectively, and their cumulative histograms at half maximum were 0.65 and 0.81 mm also with σ = 10 ps, respectively. The proposed method retrieved higher estimation accuracy of the interaction position than an existing method based on the center of gravity and principal component analysis. Therefore, it is feasible to estimate the 3D interaction position in the Cherenkov-based detectors using deep neural networks.