Endometrial Stromal Sarcoma With High-Grade Morphology and a JAZF1 Gene Rearrangement Presenting as Colonic and Cardiac Metastases: A Case Report and Review of the Literature. Issue 1 (January 2019)

• Record Type: Journal Article
• Authors: Jenkins, Taylor M.; Cooper, Kumarasen; Carolina Reyes, M.; Deshpande, Charuhas; Staats, Paul N.; Schwartz, Lauren E.; Stashek, Kristen M.
• Is Part Of: AJSP reviews & reports. Volume 24:Issue 1(2019)
• Publication Date: 2019-01
• Subjects: endometrial stromal sarcoma -- endometrial stromal tumor -- ESS -- JAZF1 -- uterine sarcoma -- YWHAE; Pathology, Surgical -- Periodicals; Pathology, Surgical; Pathologie chirurgicale; Pathology, Surgical; Electronic journals; Periodicals; 617.07
• DOI: 10.1097/PCR.0000000000000290
• Languages: English
• ISSNs: 2381-5949

Abstract

Abstract : Abstract: Endometrial stromal tumors are a heterogeneous group of tumors with varied histologies and molecular alterations. JAZF1 rearrangements are typically characteristic of low-grade lesions, high-grade lesions usually harbor YWHAE alterations, and undifferentiated uterine sarcomas commonly present with complex karyotypes. We report a case of an endometrial stromal sarcoma with a JAZF1 gene rearrangement by fluorescence in situ hybridization and high-grade cytology presenting as cardiac and colonic metastases, in a patient with a remote history of hysterectomy for to "leiomyomas."