Metal‐Free Regioselective Oxynitration of Acrylamides: Synthesis of 1, 2‐Nitro Alcohols. Issue 3 (20th February 2019)

• Record Type: Journal Article
• Authors: Gao, Le‐Han; Meng, Xiao‐Xiao; Wang, Yi‐Ning; Song, Si‐Zhe; Ge, Guo‐Ping; Dong, Youren; Wei, Wen‐Ting; Liu, Yan‐Yun; Li, Qiang
• Is Part Of: Asian journal of organic chemistry. Volume 8:Issue 3(2019)
• Page Start: 348
• Page End: 351
• Publication Date: 2019-02-20
• Subjects: metal-free -- tert-butyl nitrite -- regioselective oxynitration -- acrylamides; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201900019
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: A metal‐free oxynitration of acrylamides with commercially available tert ‐butyl nitrite and easily available air was achieved through a regioselective pathway. A wide range of 1, 2‐nitro alcohols were thus efficiently synthesized in a novel route under mild conditions. The reaction involves a radical process, allows a highly regioselective strategy toward the formation of new C−N and C−O bonds in one step. Abstract : A metal‐free oxynitration of acrylamides with commercially available tert ‐butyl nitrite and easily available air was achieved through a regioselective pathway. A wide range of 1, 2‐nitro alcohols were thus efficiently synthesized in a novel route under mild conditions. The reaction involves a radical process, allows a highly regioselective strategy toward the formation of new C−N and C−O bonds in one step.