Improving the anti-washout property of calcium phosphate cement by introducing konjac glucomannan/κ-carrageenan blend. (March 2019)

• Record Type: Journal Article
• Authors: Qian, Guowen; Li, Xingmei; He, Fupo; Ye, Jiandong
• Is Part Of: Journal of biomaterials applications. Volume 33:Number 8(2019)
• Page Start: 1094
• Page End: 1104
• Publication Date: 2019-03
• Subjects: Calcium phosphate cement -- anti-washout -- konjac glucomannan -- κ-carrageenan -- bone defect repair; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1177/0885328218824762
• Languages: English
• ISSNs: 0885-3282

Abstract

Anti-washout calcium phosphate cement (CPC) was prepared by dissolving water-soluble konjac glucomannan (KGM) and κ-carrageenan (KC) blend in the cement liquid. The anti-washout property, setting time, compressive strength and in vitro cytocompatibility of the CPC modified with KGM/KC blend were evaluated. The results indicated that the CPC pastes modified with KGM/KC blend exhibited excellent anti-washout property. The addition of KGM/KC blend shortened the setting time and increased the injectability of CPC. Although the introduction of KGM/KC blend reduced the compressive strength of CPC, the compressive strength still surpassed that of human cancellous bone. The optimal KGM/KC mass ratio was 2:8, with which the modified cement exhibited the most efficient washout resistance and the highest compressive strength. The introduction of KGM/KC blend obviously promoted the proliferation of mouse bone marrow mesenchymal stem cells. This anti-washout CPC modified by KGM/KC blend with excellent in vitro cytocompatibility will have good prospects for application in bone defect repair.