Free-Living Enterobacterium Pragia fontium 24613: Complete Genome Sequence and Metabolic Profiling. (23rd March 2017)

• Record Type: Journal Article
• Authors: Snopková, Kateřina; Sedlář, Karel; Bosák, Juraj; Chaloupková, Eva; Sedláček, Ivo; Provazník, Ivo; Šmajs, David
• Is Part Of: Evolutionary bioinformatics online. Volume 13(2017)
• Publication Date: 2017-03-23
• Subjects: Pragia fontium -- Enterobacteriaceae -- whole genome sequence -- phylogeny -- free-living bacteria; Bioinformatics -- Periodicals; Evolutionary computation -- Periodicals; Genetic programming (Computer science) -- Periodicals; Computational Biology; Evolution, Molecular; Bioinformatics; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 576.8
• DOI: 10.1177/1176934317700863
• Languages: English
• ISSNs: 1176-9343

Abstract

Pragia fontium is one of the few species that belongs to the group of atypical hydrogen sulfide-producing enterobacteria. Unlike other members of this closely related group, P. fontium is not associated with any known host and has been reported as a free-living bacterium. Whole genome sequencing and metabolic fingerprinting confirmed the phylogenetic position of P. fontium inside the group of atypical H2 S producers. Genomic data have revealed that P. fontium 24613 has limited pathogenic potential, although there are signs of genome decay. Although the lack of specific virulence factors and no association with a host species suggest a free-living style, the signs of genome decay suggest a process of adaptation to an as-yet-unknown host.