Emerging trends in the prenatal diagnosis of complex CHD and its influence on infant mortality in this cohort. (26th December 2018)

• Record Type: Journal Article
• Authors: Gorla, Sudheer R.; Chakraborty, Abhishek; Garg, Ashish; Gugol, Rubee A.; Kardon, Richard E.; Swaminathan, Sethuraman
• Is Part Of: Cardiology in the young. Volume 29:Number 3(2019)
• Page Start: 270
• Page End: 276
• Publication Date: 2018-12-26
• Subjects: Prenatal diagnosis, -- complex CHD, -- infant mortality, -- fetal echocardiography; Pediatric cardiology -- Periodicals; 618.9212
• DOI: 10.1017/S1047951118002147
• Languages: English
• ISSNs: 1047-9511

Abstract

Abstract: Background: Fetal echocardiography is the main modality of prenatal diagnosis of CHD. This study was done to describe the trends and benefits associated with prenatal diagnosis of complex CHD at a tertiary care centre. Methods: Retrospective chart review of patients with complex CHD over an 18-year period was performed. Rates of prenatal detection along with early and late infant mortality outcomes were studied. Results: Of 381 complex CHD patients born during the study period, 68.8% were diagnosed prenatally. Prenatal detection rate increased during the study period from low-50s in the first quarter to mid-80s in the last quarter (p=0.001). Rate of detection of conotruncal anomalies increased over the study period. No infant mortality benefit was noted with prenatal detection. Conclusions: Improved obstetrical screening indications and techniques have contributed to higher proportions of prenatal diagnosis of complex CHD. However, prenatal diagnosis did not confer survival benefits in infancy in our study.