Addition of blood flow restriction to passive mobilization reduces the rate of muscle wasting in elderly patients in the intensive care unit: a within-patient randomized trial. (February 2019)

• Record Type: Journal Article
• Authors: Barbalho, Matheus; Rocha, Angel Caroline; Seus, Thamires Lorenzet; Raiol, Rodolfo; Del Vecchio, Fabrício Boscolo; Coswig, Victor Silveira
• Is Part Of: Clinical rehabilitation. Volume 33:Number 2(2019)
• Page Start: 233
• Page End: 240
• Publication Date: 2019-02
• Subjects: Muscle atrophy -- passive manipulation -- intensive care unit -- blood flow restriction; Medical rehabilitation -- Periodicals; 617.03
• DOI: 10.1177/0269215518801440
• Languages: English
• ISSNs: 0269-2155

Abstract

Objective: To evaluate the addition of blood flow restriction to passive mobilization in patients in the intensive care unit. Design: The study was a within-patient randomized trial. Setting: Two intensive care units in Belém, from September to October 2017. Subjects: In total, 34 coma patients admitted to the intensive care unit sector, and 20 patients fulfilled the study requirements. Interventions: All participants received the passive mobilization protocol for lower limbs, and blood flow restriction was added only for one side in a concurrent fashion. Intervention lasted the entire patient's hospitalization time. Main outcome measurement: Thigh muscle thickness and circumference. Results: In total, 34 subjects were enrolled in the study: 11 were excluded for exclusion criteria, 3 for death, and 20 completed the intervention (17 men and 3 women; mean age: 66 ± 4.3 years). Despite both groups presented atrophy, the atrophy rate was lower in blood flow restriction limb in relation to the control limb (–2.1 vs. –2.8 mm, respectively, in muscle thickness; P = 0.001). In addition, the blood flow restriction limb also had a smaller reduction in the thigh circumference than the control limb (–2.5 vs. –3.6 cm, respectively; P = 0.001). Conclusion: The use of blood flow restriction did not present adverse effects and seems to be a valid strategy to reduce the magnitude of the rate of muscle wasting that occurs in intensive care unit patients.