An Alternative Approach to the Synthesis of New Pyrimido[5′, 4′:5, 6][1, 4] Thiazino[2, 3-B]Quinoxaline Derivatives. (April 2015)

• Record Type: Journal Article
• Authors: Bakavoli, Mehdi; Eshghi, Hosein; Azizollahi, Hamid; Saberi, Sattar; Akbarzadeh, Marziyeh
• Is Part Of: Journal of chemical research. Volume 39:Number 3(2015)
• Page Start: 174
• Page End: 176
• Publication Date: 2015-04
• Subjects: synthesis of pyrimido[5′, 4′:5, 6][1, 4]thiazine -- quinoxaline -- secondary amines -- intramolecular cyclisation -- intramolecular cyclisation; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751915X14243473376411
• Languages: English
• ISSNs: 1747-5198

Abstract

An alternative approach to the synthesis of a series of new pyrimido[5′, 4′:5, 6][1, 4]thiazino[2, 3-b]quinoxaline derivatives is described. Reaction of 5-bromo-2, 4-dichloro-6-methylpyrimidine and 3-aminoquinoxaline-2-thiol leads to the key intermediate 3-[(5-bromo-2-chloro-6-methylpyrimidin-4-yl)thio]quinoxalin-2-amine. This intermediate can be transformed into the title ring systems by subsequent treatment either with secondary amines followed by intramolecular cyclisation or initial intramolecular cyclisation with subsequent reaction with secondary amines.