A Novel and Convenient Synthesis of 3-Amino-2H-1, 2, 4-Triazoles from Isoselenocyanates and Hydrazine Hydrate. (June 2018)

• Record Type: Journal Article
• Authors: Li, Xue; Peng, Zhixiang; Zhang, Yuanyuan; Wang, Jiangwei; Gan, Bin; Xie, Yuanyuan
• Is Part Of: Journal of chemical research. Volume 42:Number 5(2018)
• Page Start: 255
• Page End: 259
• Publication Date: 2018-06
• Subjects: isoselenocyanates -- selenoureas -- hydrazine hydrate -- 3-amino-2H-1, 2, 4-triazoles; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751918X15260518865352
• Languages: English
• ISSNs: 1747-5198

Abstract

A novel and convenient one-pot synthesis of 3-amino-2 H -1, 2, 4-triazoles from two molecules of isoselenocyanates and hydrazine hydrate via cyclodeselenisation was developed. Various 3-amino-2 H -1, 2, 4-triazoles were obtained in moderate to good yields (33–45%, based on isoselenocyanates). The selenium powder and aromatic amine side products during the reaction could be recycled for efficient preparation of isoselenocyanates, which improved the atom economy. A plausible mechanism was proposed for the formation of the target products.