A Convenient Synthesis of Gimeracil. (January 2018)

• Record Type: Journal Article
• Authors: Li, Xiao-lin; Zhu, Hao-ting; Zhan, Li; Liu, Ting; Cheng, Guang; Liu, Ning; Yu, Shan-bao; Li, Hui; Luo, Yu; Yang, Fan; Tang, Jie
• Is Part Of: Journal of chemical research. Volume 42:Number 1(2018)
• Page Start: 33
• Page End: 34
• Publication Date: 2018-01
• Subjects: gimeracil -- synthesis of gimeracil -- S-1 -- protodechlorination -- SNAr; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751918X15166150010920
• Languages: English
• ISSNs: 1747-5198

Abstract

A practical three-step synthetic approach to gimeracil in a 68% overall yield is described, using 2, 4-dimethoxypyridine as the starting material with 3, 5-dichloro-2, 4-dimethoxypyridine and 3, 5-dichloro-2, 4-dihydroxypyridine as intermediates. The advantages of this procedure include short reaction steps, simple operation and good yield.