A Convenient One-Pot Synthesis of 1-Aryl-Substituted 4-Iodopyrazol-3-Ols via Aromatisation and Oxidative Iodination Reactions. (January 2018)

• Record Type: Journal Article
• Authors: Liu, Jingjing; Yang, Shanguang; Dong, Ruimei; Jin, Zhudan; Wang, Mingliang
• Is Part Of: Journal of chemical research. Volume 42:Number 1(2018)
• Page Start: 24
• Page End: 27
• Publication Date: 2018-01
• Subjects: 4-iodopyrazol-3-ols -- pyrazolidin-3-ones -- aromatisation -- oxidative iodination -- hydrogen peroxide; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751918X15161933697808
• Languages: English
• ISSNs: 1747-5198

Abstract

A convenient and economical one-pot synthesis of a series of new 1-aryl-substituted 4-iodopyrazole-3-ols from easily available pyrazolidin-3-ones in the presence of sodium iodide, 30% solution of hydrogen peroxide and a catalytic amount of sulfuric acid in dichloromethane via aromatisation and oxidative iodination reactions are described. This protocol has the advantages of high atom economy, cost-effectiveness, short reaction time and environmental friendliness.