Design, Synthesis and Antiproliferative Evaluation of 3-Aminopropyloxy Derivatives of Chalcone. (October 2016)

• Record Type: Journal Article
• Authors: Fu, Dong-Jun; Zhang, Sai-Yang; Liu, Ying-Chao; Song, Jian; Zhao, Ruo-Han; Mao, Ruo-Wang; Liu, Hong-Min; Zhang, Yan-Bing
• Is Part Of: Journal of chemical research. Volume 40:Number 10(2016)
• Page Start: 624
• Page End: 627
• Publication Date: 2016-10
• Subjects: design -- synthesis -- antiproliferative -- chalcone; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751916X14740434083371
• Languages: English
• ISSNs: 1747-5198

Abstract

A series of 3-aminopropyloxy derivatives of chalcone were synthesised and evaluated for their antiproliferative activity against liver, gastric and neuroendocrine cancer cell lines. Most of the synthesised compounds exhibited moderate to good activity against all three cancer cell lines, but in particular, a 3-(pyrrolidin-1-yl)propyloxy chalcone containing a 3, 4, 5-trimethoxyphenyl group showed the highest antiproliferative activity with an IC50 value of 2.74 μM against liver cancer cells.