Synthesis and Anticancer Activity of 4-azasteroidal-20-oxime Derivatives. (September 2015)

• Record Type: Journal Article
• Authors: Chen, Shao-Rui; Shen, Feng-Juan; Feng, Guo-Liang; Yuan, Rui-Xian
• Is Part Of: Journal of chemical research. Volume 39:Number 9(2015)
• Page Start: 527
• Page End: 530
• Publication Date: 2015-09
• Subjects: progesterone -- synthesis -- configuration -- anticancer activity; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751915X14401666837860
• Languages: English
• ISSNs: 1747-5198

Abstract

A new series of 4-azasteroidal-20-oxime derivatives have been synthesised from progesterone. All the new compounds have been characterised by analysis and spectroscopic data and subsequently evaluated for their anticancer activity in vitro against T24 cell. The studies show that the methyl and ethyl oxime-ethers exhibited higher activity than the aryl substituted oxime-esters.