Synthesis of Novel Ethyl 1-aryl-3-methyl-8-oxo-1, 8-dihydropyrano[2′, 3′:4, 5] Pyrimido[6, 1-b]Quinazoline-2-carboxylate Derivatives. (December 2016)

• Record Type: Journal Article
• Authors: Shi, Qiu-Zhong; Cao, Yong-Nan; Ma, Shi-Bing; Wang, Guo-Xi; Han, Guang-Fan; Xing, Zheng
• Is Part Of: Journal of chemical research. Volume 40:Number 12(2016)
• Page Start: 767
• Page End: 771
• Publication Date: 2016-12
• Subjects: carboxylate -- cyclisation -- fluorescence -- single crystal structure; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751916X14798109099372
• Languages: English
• ISSNs: 1747-5198

Abstract

In this paper, a new series of ethyl 1-aryl-3-methyl-8-oxo-1, 8-dihydropyrano[2′, 3′:4, 5]pyrimido[6, 1-b]quinazoline-2-carboxylate derivatives was synthesised by the cyclisation of methyl anthranilate with ethyl 5-cyano-6-[(ethoxymethylene)amino]-2-methyl-4-aryl-4H-pyran-3-carboxylate derivatives, which were obtained from reaction of triethyl orthoformate with 6-amino-5-cyano-2-methyl-4-aryl-4H- pyran-3-carboxylate derivatives. The title compounds possessed good fluorescence properties. In addition, ethyl 5-cyano-6-[(ethoxymethylene) amino]-2-methyl-4-(p-tolyl)-4H-pyran-3-carboxylate and ethyl 3-methyl-8-oxo-1-(p-tolyl)-1, 8-dihydropyrano[2′, 3′:4, 5]pyrimido[6, 1-b] quinazoline-2-carboxylate were further determined by single crystal X-ray diffraction analysis.