A Highly Efficient and Recyclable Pd(Pph3)4/Peg-400 System for Stille Cross-Coupling Reactions of Organostannanes with Aryl Bromides. (September 2017)

• Record Type: Journal Article
• Authors: Huang, Xue; Yao, Fang; Wei, Ting; Cai, Mingzhong
• Is Part Of: Journal of chemical research. Volume 41:Number 9(2017)
• Page Start: 547
• Page End: 550
• Publication Date: 2017-09
• Subjects: palladium -- Stille coupling -- aryl bromide -- PEG-400; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751917X15045169836226
• Languages: English
• ISSNs: 1747-5198

Abstract

Pd(PPh3 )4 in PEG-400 is shown to be a highly efficient catalyst for the Stille cross-coupling reactions of various organotin compounds with aryl bromides. The reaction could be conducted at 80 °C using NaOAc as base, yielding a variety of biaryls, alkynes and alkenes in good to excellent yields. The isolation of the products was readily performed by extraction with petroleum ether and the Pd(PPh3 )4 /PEG-400 system could be easily recycled and reused five times without any significant loss of activity.