Synthesis and Pharmacological Evaluation of a Novel Series of Cyclopentenone Derivatives. (January 2017)

• Record Type: Journal Article
• Authors: El-Samahy, Fatma A.; El-Hussieny, Marwa; El-Sayed, Naglaa F.; Shalaby, Elsayed M.; Osman, Fayez H.
• Is Part Of: Journal of chemical research. Volume 41:Number 1(2017)
• Page Start: 50
• Page End: 56
• Publication Date: 2017-01
• Subjects: 4-hydroxy-3, 4-diphenylcyclopent-2-enone -- cyclic secondary amines -- alkyl phosphites -- hexamethylphosphoramide -- Lawesson's reagent -- pharmacology evaluation -- single crystal X-ray diffraction; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751917X14837116219654
• Languages: English
• ISSNs: 1747-5198

Abstract

A novel series of cyclopent-2-enone derivatives have been synthesised by the reaction of 4-hydroxy-3, 4-diphenylcyclopent-2-enone, cyclic secondary amines, phosphorus reagents, hexamethylphosphoramide and Lawesson's reagent in boiling toluene/THF. The chemical structures of new compounds were identified by 1 H NMR, 13 C NMR, 31 P NMR and mass spectra. Furthermore, the structure of one of the synthesised compounds has been confirmed using single crystal X-ray diffraction. The pharmacological evaluation results of antilung and anticolon carcinoma cell line properties for the products are discussed.