Synthesis of New Substituted 5-amino-8H-phthalazino[1, 2-b]quinazolin-8-one Derivatives. (January 2017)

• Record Type: Journal Article
• Authors: Liu, Ju; Hao, Xue-Chen; Chen, Ye; Ding, Shi; Liu, Hong-Sheng; Wang, Dan
• Is Part Of: Journal of chemical research. Volume 41:Number 1(2017)
• Page Start: 18
• Page End: 20
• Publication Date: 2017-01
• Subjects: phthalazino[1, 2-b]quinazolinone -- synthesis -- easy purification; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751917X14815427219167
• Languages: English
• ISSNs: 1747-5198

Abstract

A series of novel substituted 5-amino-8 H -phthalazino[1, 2- b ]quinazolin-8-one derivatives synthesised by condensation of different amines with 5-chloro-8 H -phthalazino[1, 2- b ]quinazolin-8-one, which was prepared from methyl 2-aminobenzoate by condensation with hydrazine hydrate and then cyclisation with a phthalic anhydride in N, N -dimethylacetamide at refluxing condition. The intermediate and target compounds were obtained in good yields and were easily purified by filtration or recrystallisation.