Synthesis of a reactive oxygen species responsive heterobifunctional thioketal linker. Issue 37 (9th September 2015)

• Record Type: Journal Article
• Authors: Ling, Xiaoxi; Zhang, Shaojuan; Shao, Pin; Wang, Pengcheng; Ma, Xiaochao; Bai, Mingfeng
• Is Part Of: Tetrahedron letters. Volume 56:Issue 37(2015)
• Page Start: 5242
• Page End: 5244
• Publication Date: 2015-09-09
• Subjects: Thioketal -- Reactive oxygen species -- Stimuli responsive linker -- Protecting group -- Esterase -- Reaction kinetics; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.07.059
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A new heterobifunctional reactive oxygen species (ROS) responsive thioketal linker and its synthesis are described. This linker allows for developing new ROS-responsive agents with two distinct functionalities using universal bioconjugation methods. The reaction kinetics of the thioketal cleavage in the presence of ROS is also described.