Antiviral carboxylic acids and naphthoquinones from the stems of Rhinacanthus nasutus. Issue 37 (9th September 2015)

• Record Type: Journal Article
• Authors: Thongchuai, Benchaluk; Tragoolpua, Yingmanee; Sangthong, Padchanee; Trisuwan, Kongkiat
• Is Part Of: Tetrahedron letters. Volume 56:Issue 37(2015)
• Page Start: 5161
• Page End: 5163
• Publication Date: 2015-09-09
• Subjects: Carboxylic acid -- Rhinacanthus nasutus -- Antiviral activity -- Cytotoxic activity; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.07.082
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Three new carboxylic acids, rhinacanthinic acids A–C (1 –3 ), together with six known naphthoquinones and one known δ-lactone were isolated from the stems of Rhinacanthus nasutus . The structures of the isolated compounds were elucidated based on spectroscopic evidence. Their antiviral activity against herpes simplex virus type-2 (HSV-2) and cytotoxicity were examined.