Functional network centrality in obesity: A resting-state and task fMRI study. Issue 3 (30th September 2015)

• Record Type: Journal Article
• Authors: García-García, Isabel; Jurado, María Ángeles; Garolera, Maite; Marqués-Iturria, Idoia; Horstmann, Annette; Segura, Bàrbara; Pueyo, Roser; Sender-Palacios, María José; Vernet-Vernet, Maria; Villringer, Arno; Junqué, Carme; Margulies, Daniel S.; Neumann, Jane
• Is Part Of: Psychiatry research. Volume 233:Issue 3(2015)
• Page Start: 331
• Page End: 338
• Publication Date: 2015-09-30
• Subjects: AFNI Analysis of Functional Neuroimages -- BMI body-mass index -- FSL FMRIB Software Library -- fMRI functional magnetic resonance imaging -- ICA independent component analysis -- SCID-I Structured Clinical Interview for DSM-IV -- SPM statistical parametric mapping; Body-mass index -- fMRI -- Functional connectivity -- Graph analysis -- Brain; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2015.05.017
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: Obesity is associated with structural and functional alterations in brain areas that are often functionally distinct and anatomically distant. This suggests that obesity is associated with differences in functional connectivity of regions distributed across the brain. However, studies addressing whole brain functional connectivity in obesity remain scarce. Here, we compared voxel-wise degree centrality and eigenvector centrality between participants with obesity ( n =20) and normal-weight controls ( n =21). We analyzed resting state and task-related fMRI data acquired from the same individuals. Relative to normal-weight controls, participants with obesity exhibited reduced degree centrality in the right middle frontal gyrus in the resting-state condition. During the task fMRI condition, obese participants exhibited less degree centrality in the left middle frontal gyrus and the lateral occipital cortex along with reduced eigenvector centrality in the lateral occipital cortex and occipital pole. Our results highlight the central role of the middle frontal gyrus in the pathophysiology of obesity, a structure involved in several brain circuits signaling attention, executive functions and motor functions. Additionally, our analysis suggests the existence of task-dependent reduced centrality in occipital areas; regions with a role in perceptual processes and that are profoundly modulated by attention. Highlights: We examined functional network centrality in obesity. We acquired resting-state and task-related data from the same subjects. We found obesity-related lower degree centrality in the middle frontal gyrus. Differences in the middle frontal gyrus seemed to be trait-dependent.