[bmim]PF6/KOH: A Recyclable Catalytic System for an Azide–Arylacetaldehyde [3 + 2] Cycloaddition. (November 2017)

• Record Type: Journal Article
• Authors: Jiang, Yuqin; Wu, Kai; Tan, Xuxia; Zhang, Dandan; Dong, Wenpei; Li, Wei; Xu, Guiqing; Zhang, Weiwei
• Is Part Of: Journal of chemical research. Volume 41:Number 11(2017)
• Page Start: 631
• Page End: 635
• Publication Date: 2017-11
• Subjects: 1, 4-disubstituted 1, 2, 3-triazoles -- ionic liquid [bmim]PF6/KOH -- arylacetaldehydes; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751917X15094552081152
• Languages: English
• ISSNs: 1747-5198

Abstract

A fast and green protocol for the synthesis of 1, 4-disubstituted 1, 2, 3-triazoles from azides and arylacetaldehydes at room temperature was developed using [bmim]PF6 /KOH as the reaction medium. It was found that the in situ -generated carbene from [bmim]PF6 /KOH acted as the catalyst. In the absence of a transition-metal catalyst and organic solvent, this azide–arylacetaldehyde [3 + 2] cycloaddition proceeds efficiently, with high levels of regioselectivity, broad range of substrates, excellent yields and simple operation under mild conditions.