Synthesis of Novel Spiro(Indolizine-Pyrazole) Derivatives via 1, 3-Dipolar Cycloaddition of Nitrilimine. (October 2017)

• Record Type: Journal Article
• Authors: Zhang, Shaowei; Hu, Xiaolian; Tao, Hongwen; Liu, Haochong; Li, Xiaofang
• Is Part Of: Journal of chemical research. Volume 41:Number 10(2017)
• Page Start: 608
• Page End: 610
• Publication Date: 2017-10
• Subjects: indolizine -- spiroheterocycle -- 1, 3-dipolar cycloaddition -- nitrilimine; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751917X15064232103100
• Languages: English
• ISSNs: 1747-5198

Abstract

The 1, 3-dipolar cycloaddition of nitrilimine, generated in situ from N ′-phenylbenzohydrazonoyl chloride and triethylamine, to 7-arylmethylidene-6, 7-dihydroindolizin-8( 5H )-one afforded novel 4′-aryl-2′, 5′-diphenyl-2′, 4′, 5, 6-tetrahydro-8 H -spiro(indolazine-7, 3′-pyrazol)-8-ones in moderate yields. The structures of all the products were characterised thoroughly by NMR, infrared spectroscopy and HRMS. The structure and stereochemistry was confirmed by X-ray diffraction analysis.