An Efficient Synthesis of 2, 4-Difluoro-3, 5-Dichlorobenzoic Acid. (May 2015)

• Record Type: Journal Article
• Authors: Zhou, Weiyou; Yu, Shuitao; Xia, Zhengjun; Zhang, Mingguang; Lin, Song; Chen, Zaixin
• Is Part Of: Journal of chemical research. Volume 39:Number 5(2015)
• Page Start: 277
• Page End: 278
• Publication Date: 2015-05
• Subjects: quinolone-3-carboxylic acids derivatives -- 2, 4-difluoro-3, 5-dichlorobenzoic acid -- synthesis; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751915X14295255352061
• Languages: English
• ISSNs: 1747-5198

Abstract

2, 4-Difluoro-3, 5-dichlorobenzoic acid, as a key intermediate for preparing quinolone-3-carboxylic acids, was synthesised from the commercially available 2, 4-difluoro-3-chlorobenzoic acid in excellent yield by a reaction sequence involving nitration, selective reduction, diazotisation and chlorination.