A Green, Facile Approach for the Multicomponent Synthesis of Bioactive Spiro[Indoline-3, 7′-Pyrrolo[1, 2-c]Imidazole] Derivatives. (February 2015)

• Record Type: Journal Article
• Authors: Shen, Tianhua; Zhou, Yongbing; Che, Fengfeng; Yu, Jiangxia; Lin, Yan; Song, Qingbao
• Is Part Of: Journal of chemical research. Volume 39:Number 2(2015)
• Page Start: 115
• Page End: 119
• Publication Date: 2015-02
• Subjects: spiro[indoline-3, 7′-pyrrolo[1, 2-c]imidazole] derivatives -- water -- inhibitory activities -- multicomponent reaction; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751915X14229612721445
• Languages: English
• ISSNs: 1747-5198

Abstract

An efficient synthesis of spiro[indoline-3, 7′-pyrrolo[1, 2-c]imidazole] is achieved through a three-component reaction of isatins, malononitrile, and hydantoin/2-thiohydantoin in water catalysed by NaHCO3 . All the target compounds were screened for the Cell Division Cycle 25 Phosphatase B (CDC25B) inhibitory activities.