Convenient Route to Trisubstituted Oxazoles via a Copper-Catalysed Tandem Oxidative Cyclisation by Oxygen Oxidation. (January 2015)

• Record Type: Journal Article
• Authors: Chen, Chengqun; Chen, Wenfu; Bao, Qianhong
• Is Part Of: Journal of chemical research. Volume 39:Number 1(2015)
• Page Start: 7
• Page End: 10
• Publication Date: 2015-01
• Subjects: copper -- oxazoles -- β-diketones -- benzylamine -- oxygen oxidation; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751915X14192609116136
• Languages: English
• ISSNs: 1747-5198

Abstract

A novel copper-catalysed oxidative cyclisation has been developed for the synthesis of trisubstituted oxazoles, which is thought to proceed through cascade formation of C-N and C-O bonds by oxygen oxidation. The desired products can be obtained from readily available starting materials while avoiding hazardous materials. Therefore, a green synthetic method for the preparation of oxazoles has been found.