Synthesis of Novel 2-Methyl and 2-Cyanomethyl-12-Aryl-8, 12-Dihydro-9H-cHromeno[3, 2-e][1, 2, 4]Triazolo[1, 5-c]Pyrimidin-11(10H)-One Derivatives. (January 2015)

• Record Type: Journal Article
• Authors: Li, Bei; Wang, Zhong-Xia; Xing, Zheng; Chen, Li-Zhuang; Han, Guang-Fan
• Is Part Of: Journal of chemical research. Volume 39:Number 1(2015)
• Page Start: 30
• Page End: 35
• Publication Date: 2015-01
• Subjects: chromeno[3, 2-e][1, 2, 4]triazolo[1, 5-c]pyrimidine-11(10H)-one -- formimidate -- synthesis of triazolopyrimidines; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751915X14190040330104
• Languages: English
• ISSNs: 1747-5198

Abstract

2-Methyl and 2-cyanomethyl-12-aryl-8, 12-dihydro-9H-chromeno[3, 2-e][1, 2, 4]triazolo[1, 5-c]pyrimidin-11(10H)-one derivatives were synthesised by the cyclisations of acetic anhydride or ethyl cyanoacetate with chromeno[2, 3-d]pyrimidine derivatives, which were obtained by the reactions of hydrazine monohydrate and formimidate derivatives. In addition, 2, 9, 9-trimethyl-12-(p-tolyl)-8, 12-dihydro-9H-chromeno[3, 2-e][1, 2, 4]triazolo[1, 5-c]pyrimidin-11(10H)-one and 2-cyanomethyl-12-phenyl-8, 12-dihydro-9H-chromeno[3, 2-e][1, 2, 4]triazolo[1, 5-c]pyrimidin-11(10H)-one were further determined by single-crystal X-ray diffraction analysis.