An Improved Synthesis of 6-O-Methyl-Scutellarein through Selective Benzylation. (November 2015)

• Record Type: Journal Article
• Authors: Zhang, Wei; Dong, Ze-Xi; Gu, Ting; Li, Nian-Guang; Wu, Wen-Yu; Zhang, Peng-Xuan; Tang, Yu-Ping; Yang, Jian-Ping; Xue, Xin; Fang, Fang; Li, He-Min; Cheng, Hai-Bo; Duan, Jin-Ao; Shi, Zhi-Hao
• Is Part Of: Journal of chemical research. Volume 39:Number 11(2015)
• Page Start: 674
• Page End: 676
• Publication Date: 2015-11
• Subjects: scutellarin -- scutellarein -- 6-O-methyl-scutellarein -- metabolite -- selective benzylation; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751915X14452625043383
• Languages: English
• ISSNs: 1747-5198

Abstract

An improved synthesis of 6-O-methyl-scutellarein is described. Benzyl bromide was selected to protect both the hydroxyl groups at C-4′ and C-7 in scutellarein. The product was then methylated and deprotected to produce the target compound in high yield in four steps.