Growth rate of serous pancreatic neoplasms in vivo: a retrospective, observational study. (April 2019)

• Record Type: Journal Article
• Authors: Park, Chan; Kim, Hyoung Jung; Kim, So Yeon; Lee, Seung Soo; Byun, Jae Ho; Kim, Song Cheol; Kim, Myung-Hwan
• Is Part Of: Acta radiologica. Volume 60:Number 4(2019)
• Page Start: 433
• Page End: 440
• Publication Date: 2019-04
• Subjects: Serous pancreatic neoplasm -- serous cystic neoplasm -- serous cystadenoma -- pancreas -- growth rate -- CT; Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/0284185118787350
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: Determining the growth rate of pancreatic cystic lesions on follow-up imaging is important in managing patients with these lesions. However, the growth rates of serous pancreatic neoplasms (SPNs) have been reported to vary among studies. Purpose: To determine the in vivo growth rate of SPNs. Material and Methods: This retrospective, single-institutional study included patients diagnosed with SPNs during 2006–2015. The diagnosis of SPNs was based on the results of surgery, endoscopic ultrasonography (EUS)-guided fine needle aspiration (FNA) or core needle biopsy (CNB), or typical radiologic features of SPN. A linear mixed-effects model was utilized to determine whether the diagnostic intervention was associated with tumor growth rate in all patients. The in vivo growth rate of SPNs was estimated from patients without or before diagnostic intervention. SPN growth rates were compared before and after diagnostic intervention. Results: SPN growth rates in the overall patient cohort (n = 304) differed significantly between patients who did and did not undergo diagnostic interventions. The in vivo SPN growth rate in 204 patients without or before diagnostic intervention was 1.9 mm/year (95% confidence interval [CI] = 1.6–2.2). In the 130 patients who underwent diagnostic intervention, the SPN growth rate was significantly greater before than after diagnostic intervention (1.8 vs. 0.2 mm/year). Conclusions: In the absence of diagnostic intervention, the in vivo growth rate of SPNs was 1.9 mm/year (95% CI = 1.6–2.2). EUS-guided FNA or CNB may affect the growth rate of SPNs.