Assessment of circulating tumor DNA in pediatric solid tumors: The promise of liquid biopsies. Issue 5 (6th January 2019)

• Record Type: Journal Article
• Authors: Abbou, Samuel D.; Shulman, David S.; DuBois, Steven G.; Crompton, Brian D.
• Is Part Of: Pediatric blood & cancer. Volume 66:Issue 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-01-06
• Subjects: circulating tumor DNA -- pediatric cancer -- next‐generation sequencing -- digital PCR -- liquid biopsy; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.27595
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Circulating tumor DNA can be detected in the blood and body fluids of patients using ultrasensitive technologies, which have the potential to improve cancer diagnosis, risk stratification, noninvasive tumor profiling, and tracking of treatment response and disease recurrence. As we begin to apply "liquid biopsy" strategies in children with cancer, it is important to tailor our efforts to the unique genomic features of these tumors and address the technical and logistical challenges of integrating biomarker testing. This article reviews the literature demonstrating the feasibility of applying liquid biopsy to pediatric solid malignancies and suggests new directions for future studies.