Synthesis and characterisation of some novel fused thiazolo[3, 2-a]pyrimidinones and pyrimido[2, 1-b][1, 3]thiazinones. (1st December 2015)

• Record Type: Journal Article
• Authors: Abbas, Ikhlass; Gomha, Sobhi; Elaasser, Mahmoud; Mabrouk, Bazada
• Is Part Of: Journal of chemical research. Volume 39:Number 12(2015)
• Page Start: 719
• Page End: 723
• Publication Date: 2015-12-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751915X14474391581067
• Languages: English
• ISSNs: 1747-5198

Abstract

Reactions of 7, 9-bis(4-methoxyphenyl)-2-thioxo-2, 3-dihydropyrido[3', 2':4, 5]thieno[3, 2-d]pyrimidin-4(1H)-one with α-haloketones, chloroacetonitrile and DMAD, afforded the corresponding fused thiazolo[3, 2-a]pyrimidinone derivatives. The reaction of the thione with chloroacetic acid and an appropriate aromatic aldehyde yielded the respective 2-arylidene-2H-pyrido[3', 2':4, 5]thieno[3, 2-d]thiazolo[3, 2-a] pyrimidine-3, 5-diones. Also, the treatment of thione with arylidenemalononitriles gave the fused pyrimido[2, 1-b][1, 3]thiazine derivatives, respectively. The structures of the synthesised products were confirmed by IR, 1H NMR and mass spectral techniques. The cytotoxic activity of the new products against breast carcinoma (MCF-7) and hepatocellular carcinoma (HepG2) cell lines were determined and the results revealed promising activity.