Hydrazonoyl chlorides in the synthesis of pyrazolo[5, 1-c][1, 2, 4]triazole derivatives and their biological activities. (1st August 2016)

• Record Type: Journal Article
• Authors: Farghaly, Thoraya; Gomha, Sobhi; Mousa, Eman; Elaasser, Mahmoud
• Is Part Of: Journal of chemical research. Volume 40:Number 8(2016)
• Page Start: 467
• Page End: 470
• Publication Date: 2016-08-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751916X14664365099510
• Languages: English
• ISSNs: 1747-5198

Abstract

A new series of 7-arylazopyrazolo[5, 1-c][1, 2, 4]triazoles was synthesised via reaction of 3-amino-4-(arylhydrazono)-4, 5-dihydropyrazol-5ones with hydrazonoyl halides using triethylamine as a basic catalyst. The structure of all the synthesised compounds was confirmed on the basis of elemental and spectral analyses. Moreover, the antimicrobial and antitumour activities of these compounds were evaluated and the results obtained indicate the weak efficacy of some of them as antibacterial agents. However, the results of antitumour activity against HepG-2 liver cancer and HCT-116 colon cancer of some derivatives showed good activity in comparison with the reference drugs.