Cascade Reactions Utilizing the Nucleophilic Properties of 1, 1‐Enediamines for the Regioselective Synthesis of 4‐Aryl‐2‐aminopyridines. Issue 11 (18th March 2019)

• Record Type: Journal Article
• Authors: Kong, Ling‐Bin; Yan, Sheng‐Jiao; Yao, Yuan; Xiao, Qiang; Lin, Jun
• Is Part Of: ChemistrySelect. Volume 4:Issue 11(2019)
• Page Start: 3083
• Page End: 3087
• Publication Date: 2019-03-18
• Subjects: 4-Aryl-2-aminopyridines -- Cascade reaction -- 1, 1-Enediamines -- Nitro group -- Regioselective synthesis; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201900026
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The novel 4‐aryl‐2‐aminopyridine compounds 3 have been synthesised via the regioselective cascade reaction of 1, 1‐enediamines (EDAMs) 1 with ( E )‐ethyl 2‐oxo‐4‐phenylbut‐3‐enoates 2 in EtOH promoted by piperidine. The reactions have the advantages of using an environmen tally friendly solvent and inexpensive starting compounds to produce good to moderate yield. This method provides a concise procedure for the highly regioselective synthesis of 4‐aryl‐2‐aminopyridine compounds. Abstract : The novel 4‐aryl‐2‐aminopyridines have been synthesised via the regioselective cascade reaction of EDAMs with ( E )‐ethyl 2‐oxo‐4‐phenylbut‐3‐enoates in EtOH promoted by piperidine. The reactions have the advantages of having good yield and inexpensive starting compounds. This method provides a concise procedure for the highly regioselective synthesis of 4‐aryl‐2‐aminopyridine compounds.