Dehydroepiandrosterone sulfate/free androgen index ratio predicts a favorable metabolic profile in patients with polycystic ovary syndrome. (1st February 2019)

• Record Type: Journal Article
• Authors: Nadir, Ahmet; Temizkan, Sule; Ozderya, Aysenur; Temizkan, Osman; Orbay, Ekrem; Aydin, Kadriye
• Is Part Of: Gynecological endocrinology. Volume 35:Number 2(2019)
• Page Start: 128
• Page End: 132
• Publication Date: 2019-02-01
• Subjects: Polycystic ovary syndrome (PCOS) -- dehydroepiandrosterone sulfate (DHEAS) -- free androgen index (FAI) -- triglyceride (TG) -- high-density lipoprotein cholesterol (HDL-C); Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2018.1505843
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Potential effect of hyperandrogenemia on metabolic disturbances in polycystic ovary syndrome (PCOS) has always been a matter of interest. We analyzed the records of 125 patients with PCOS and 54 age-matched healthy women. All participants underwent biochemical and hormonal assessment and a 75 g oral glucose tolerance test was performed. PCOS and control groups were comparable in terms of age. Dehydroepiandrosterone sulfate/free androgen index( DHEAS/FAI) ratio was negatively correlated with body mass index (BMI) ( p < .001), fasting glucose ( p = .02), area under the curve (AUC) of glucose ( p = .03), AUC of insulin ( p = .001), homeostasis model assessment-estimated insulin resistance (HOMA-IR) ( p < .001), and triglycerides (TG) ( p = .009), and positively correlated with insulin sensitivity index (ISI) ( p < .001) and high-density lipoprotein cholesterol (HDL-C) ( p < .001) among PCOS patients. In logistic regression analysis, higher DHEAS/FAI ratio levels were associated with lower risk of low HDL-C [RR(95%CI); 0.97(0.95–0.98); p < .001] as well as atherogenic dyslipidemia (TG/HDL-C) [RR(95%CI); 0.97(0.94–0.99); p = .035] even after adjustment for BMI in the PCOS group. Androgens, DHEAS and FAI act differently on metabolic parameters. Our results demonstrate that high DHEA-S/FAI ratio levels are associated with a more favorable metabolic profile.