Reversible chemoselective transetherification of vinylogous esters using Fe-catalyst under additive free conditions. Issue 12 (8th March 2019)

• Record Type: Journal Article
• Authors: Parvathalu, Nenavath; Agalave, Sandip G.; Mohanta, Nirmala; Gnanaprakasam, Boopathy
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 12(2019)
• Page Start: 3258
• Page End: 3266
• Publication Date: 2019-03-08
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob00307j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An additive/Brønsted acid/base free, highly efficient and chemoselective transetherification of vinylogous esters and water mediated de-alkylation using Fe-catalyst is described. Abstract : An additive/Brønsted acid/base free, highly efficient and chemoselective transetherification of electron deficient vinylogous esters and water mediated de-alkylation using an earth-abundant Fe-catalyst under very mild reaction conditions is described. This reaction is highly selective to primary alcohols over secondary alcohols, has good functional group tolerance, is scalable to gram scale and a purification free sequential transetherification in a continuous flow mode is demonstrated.