Particokinetics and in vitro dose of high aspect ratio nanoparticles. Issue 12 (13th March 2019)

• Record Type: Journal Article
• Authors: Price, Seth Richard; Kinnear, Calum; Balog, Sandor
• Is Part Of: Nanoscale. Volume 11:Issue 12(2019)
• Page Start: 5209
• Page End: 5214
• Publication Date: 2019-03-13
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c9nr00976k
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Adapting computational particokinetic models to address the dosage of high-aspect ratio nanomaterials for in vitro nanoparticle toxicology assays involving submerged adherent cell cultures. Abstract : Computational particokinetics models become essential in the design and interpretation of in vitro nanoparticle toxicology assays involving submerged adherent cell cultures. Yet, none of the current models offers the possibility of addressing the delivered dose of high-aspect ratio nanoparticles, including nanorods, nanotubes, and nanofibers. Here we present a straightforward method that lends this ability to any of the models used currently.