Metal-free aza-Claisen type ring expansion of vinyl aziridines: an expeditious synthesis of seven membered N-heterocycles. Issue 12 (15th January 2019)

• Record Type: Journal Article
• Authors: Singh, Deepak; Ha, Hyun-Joon
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 12(2019)
• Page Start: 3093
• Page End: 3097
• Publication Date: 2019-01-15
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob03029d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A metal-free approach for the synthesis of 7-membered aza-heterocycles has been developed by the intermolecular [5 + 2] cycloaddition of non-activated vinylaziridines and alkynes. Abstract : A metal-free approach for the synthesis of 7-membered aza-heterocycles has been developed by the intermolecular [5 + 2] cycloaddition of non-activated vinylaziridines and alkynes. This method has a broad substrate scope under mild reaction conditions to afford structurally diverse 7-membered N-heterocycles in high yield up to 92%.