Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registry. (March 2019)

• Record Type: Journal Article
• Authors: Antonio González-Hermosillo, J.; Baños-González, Manuel A.; Guevara-Valdivia, Milton E.; Vázquez-Acosta, Jorge A.; de los Ríos Ibarra, Manuel Odín; Aguilar-Linares, Kulio A.; Cantú-Brito, Carlos; Leiva-Pons, José L.; Pozas-Garza, Gerardo; Favela-Pérez, Eddie A.; Márquez, Manlio F.
• Is Part Of: IJC heart & vasculature. Volume 22(2019)
• Page Start: 117
• Page End: 122
• Publication Date: 2019-03
• Subjects: AF Atrial fibrillation -- APD Antiplatelet drugs -- ATT Antithrombotic therapy -- DOAC Direct oral anticoagulants -- VKA Vitamin K antagonists; Atrial fibrillation -- Gender -- Thromboembolic risk -- Antithrombotic therapy -- Stroke -- Mexico; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Pathophysiology -- Periodicals; 616.1005
• DOI: 10.1016/j.ijcha.2018.12.017
• Languages: English
• ISSNs: 2352-9067

Abstract

Abstract: Background: Atrial Fibrillation (AF) is associated with an increased risk of stroke and systemic embolism. Several studies have suggested that female AF patients could have a greater risk for stroke. There is scarce information about clinical characteristics and use of antithrombotic therapies in Latin American patients with nonvalvular AF. Objective: To describe the gender differences in clinical characteristics, thromboembolic risk, and antithrombotic therapy of patients with nonvalvular AF recruited in Mexico, an upper middle-income country, into the prospective national CARMEN-AF Registry. Methods: A total of 1423 consecutive patients, with at least one thromboembolic risk factor were enrolled in CARMEN-AF Registry during a three-year period (2014–2017). They were categorized according to Gender. Results: Overall, 48.6% were women, mean age 70 ± 12 years. Diabetes, smoking, alcoholism, non-ischemic cardiomyopathy, coronary artery disease, and obstructive sleep apnea were higher in men. Most women were found with paroxysmal AF (40.6%), and most men with permanent AF (44.0%). No gender differences were found in the use of vitamin K antagonists (VKA) (30.5% in women vs. 28.0% in men). No gender differences were found in the use of direct oral anticoagulants (DOAC) (33.8% women vs 35.4% men). Conclusions: CARMEN-AF Registry demonstrates that in Mexico, regardless of gender, a large proportion of patients remain undertreated. No gender differences were found in the use of VKA or DOAC.