Dietary inflammatory potential and risk of mortality in metabolically healthy and unhealthy phenotypes among overweight and obese adults. Issue 2 (April 2019)

• Record Type: Journal Article
• Authors: Park, Yong-Moon Mark; Choi, Moon Kyung; Lee, Seong-Su; Shivappa, Nitin; Han, Kyungdo; Steck, Susan E.; Hébert, James R.; Merchant, Anwar T.; Sandler, Dale P.
• Is Part Of: Clinical nutrition. Volume 38:Issue 2(2019)
• Page Start: 682
• Page End: 688
• Publication Date: 2019-04
• Subjects: National Health and Nutrition Examination Survey III -- Dietary inflammatory index -- Overweight -- Obesity -- Metabolic health -- Mortality; DII Dietary Inflammatory Index -- CVD Cardiovascular Disease -- MHO Metabolically Healthy Overweight/Obese -- MUO Metabolically Unhealthy Overweight/Obese -- NHANES National Health and Nutrition Examination Survey -- HDL-C High-Density Lipoprotein Cholesterol; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2018.04.002
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: This study was designed to investigate the association between the dietary inflammatory index (DII ® ) scores, metabolic phenotypes, and risk of mortality risk in overweight/obese individuals from a representative sample of the U.S. population. Methods: Data from 3733 overweight/obese adults (BMI ≥ 25 kg/m 2 ) aged 20–90 years from the National Health and Nutrition Examination Survey III, 1988–1994 were analyzed; these participants were followed for mortality through December 31, 2011. DII scores were computed based on baseline dietary intake using 24-h dietary recalls. Metabolically unhealthy status was defined as having 2 or more of these metabolic abnormalities: high glucose, insulin resistance, elevated blood pressure, triglycerides, C-reactive protein levels, or low high-density lipoprotein-cholesterol values. Results: In metabolically unhealthy overweight/obese (MUO) individuals, DII score was associated with increased risk of all-cause mortality (HRTertile 3 vs Tertile 1 1.44; 95% CI 1.11–1.86 Ptrend = 0.008; HR1SD increase 1.08; 95% CI 0.99–1.18). Additionally, a stronger association with cardiovascular mortality was observed (HRT3 vs T1 3.29; 95% CI 2.01–5.37 Ptrend < 0.001; HR1SD increase 1.40; 95% CI 1.18–1.66), after adjusting for potential confounders. Furthermore, when analyses were restricted to obese individuals (BMI ≥ 30 kg/m 2 ), the association was more pronounced, especially for cardiovascular mortality (HRT3 vs T1 5.55; 95% CI 2.11–14.57 Ptrend = 0.006; HR1SD increase 1.74; 95% CI 1.21–2.50). No association was observed between DII score and risk of mortality in individuals with metabolically healthy overweight/obese (MHO) phenotype, or for cancer mortality in either MHO or MUO phenotype. Conclusions: A pro-inflammatory diet appears to increase risk of all-cause and cardiovascular mortality in the MUO phenotype, but not among the MHO phenotype.