Border disease in cattle. (April 2019)

• Record Type: Journal Article
• Authors: Braun, Ueli; Hilbe, Monika; Peterhans, Ernst; Schweizer, Matthias
• Is Part Of: Veterinary journal. Volume 246(2019)
• Page Start: 12
• Page End: 20
• Publication Date: 2019-04
• Subjects: AGID agarose gel immunodiffusion -- BDV Border disease virus -- BVD bovine viral diarrhoea -- BVDV bovine viral diarrhoea virus -- CT computer tomography -- Cp cytopathic -- CSFV classical swine fever virus -- Ct cycle threshold -- ELISA enzyme-linked immunosorbent assay -- IHC immunohistochemistry -- Ncp non-cytopathic -- NPro n-terminal protease region -- OD optical density -- ORF open reading frame -- RNA ribonucleic acid -- RT-PCR real-time polymerase chain reaction -- SNT serum neutralisation test -- TCID tissue culture infective dose -- UTR untranslated region; Border disease -- Bovine viral diarrhoea -- Cattle -- Clinical findings -- Epidemiology; Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2019.01.006
• Languages: English
• ISSNs: 1090-0233

Abstract

Graphical abstract: Highlights: Border disease virus (BDV) is especially important in countries that eradicate bovine virus diarrhoe virus (BVDV). The clinical course of BDV infection is similar to BDVD infection and the laboratory differentiation is challenging. The most important factor in BDV transmission is direct contact between sheep persistently infected with BDV and cattle. To prevent BDV transmission from sheep to cattle, separate housing or pasturing of sheep and cattle is recommended. Abstract: Within the family Flaviviridae, viruses within the genus Pestivirus, such as Border disease virus (BDV) of sheep, can cause great economic losses in farm animals. Originally, the taxonomic classification of pestiviruses was based on the host species they were isolated from, but today, it is known that many pestiviruses exhibit a broad species tropism. This review provides an overview of BDV infection in cattle. The clinical, hematological and pathological–anatomical findings in bovines that were transiently or persistently infected with BDV largely resemble those in cattle infected with the closely related pestivirus bovine viral diarrhoea virus (BVDV). Accordingly, the diagnosis of BDV infection can be challenging, as it must be differentiated from various pestiviruses in cattle. The latter is very relevant in countries with control programs to eradicate BVDV in Bovidae, as in most circumstances, pestivirus infections in sheep, which act as reservoir for BDV, are not included in the eradication scheme. Interspecies transmission of BDV between sheep and cattle occurs regularly, but BDV in cattle appears to be of minor general importance. Nevertheless, BDV outbreaks at farm or local level can be very costly.