Efficient chemoenzymatic synthesis of UDP-α-6-N3-glucose. Issue 9 (1st May 2019)

• Record Type: Journal Article
• Authors: Wang, Jiajia; Zhang, Dongzhe; Wen, Yinhang; Cao, Xuefeng; Ma, Jing; George Wang, Peng
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 29:Issue 9(2019)
• Page Start: 1148
• Page End: 1151
• Publication Date: 2019-05-01
• Subjects: Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2019.02.002
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: A novel chemo-enzymatic synthetic method for UDP-α-6-N3 -glucose was developed by combining the versatility of chemical synthesis and natural enzyme stereo-selectivity of Bifidobacterium longum (BLUSP). This flexible and efficient platform expanded the substrate scope for UDP-sugars on an improved scale, particularly for UDP-sugar substrates containing bioorthogonal functional groups.