Facile synthesis of dual-functional nanoparticles co-loaded with ZnPc/Fe3O4 for PDT and magnetic resonance imaging. (June 2019)

• Record Type: Journal Article
• Authors: Qin, Jinglei; Peng, Hongshang; Ping, Jiantao; Geng, Zhaoxin
• Is Part Of: Materials research bulletin. Volume 114(2019)
• Page Start: 90
• Page End: 94
• Publication Date: 2019-06
• Subjects: Nanoparticle -- ZnPc -- Fe3O4 -- PDT -- MRI; Materials -- Periodicals; Crystal growth -- Periodicals; Matériaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Crystal growth; Materials; Periodicals; 620.11
• DOI: 10.1016/j.materresbull.2019.02.020
• Languages: English
• ISSNs: 0025-5408

Abstract

Graphical abstract: Highlights: Biocompatible ZnPc/Fe3 O4 co-loaded NPs were one-step prepared using a reprecipitation-encapsulation method. The nanophotosensitizers could be collected effortlessly by a magnet. Aggregation of ZnPc in nanophotosensitizers was greatly improved by the co-encapsulation of Fe3 O4 NPs. The dual-functional NPs exhibited high photocytotoxicity ( in vitro PDT) as well as a high r2 relaxivity value (MRI). Abstract: In this work, a class of dual-functional nanoparticles (NPs) were facilely prepared from ZnPc and Fe3 O4 NPs for photodynamic therapy (PDT) and magnetic resonance imaging (MRI). The as-synthesized NPs were investigated in terms of size, morphology, zeta potential, biocompatibility, optical and magnetic properties respectively. The aggregation degree of ZnPc in hybrid NPs was found to be considerably meliorated with the presence of Fe3 O4 NPs, corresponding to higher 1 O2 generation rate. Based on the dual-functional NPs, MRI and in vitro PDT was carried out, respectively, yielding a high r2 relaxivity value of 152.9 mM −1 s −1 and strong photocytotoxicity. Given the facility of synthesis, such a strategy can be applied to prepare other multifunctional NPs by introducing other small-sized NPs, such as Au NPs (photothermal), quantum dots (fluorescence imaging), etc.