Vitamin D nutritional status and bone turnover markers in childhood acute lymphoblastic leukemia survivors: A PETALE study. Issue 2 (April 2019)

• Record Type: Journal Article
• Authors: Delvin, E.; Alos, N.; Rauch, F.; Marcil, V.; Morel, S.; Boisvert, M.; Lecours, M.-A.; Laverdière, C.; Sinnett, D.; Krajinovic, M.; Dubois, J.; Drouin, S.; Lefebvre, G.; Samoilenko, M.; Nyalendo, C.; Cavalier, E.; Levy, E.
• Is Part Of: Clinical nutrition. Volume 38:Issue 2(2019)
• Page Start: 912
• Page End: 919
• Publication Date: 2019-04
• Subjects: Acute lymphoblastic leukemia -- 25-Hydroxyvitamin D3 -- Bone resorption -- Bone formation -- CTX -- P1NP; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2018.02.006
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background: The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk of impaired skeletal mass accumulation during childhood and adolescence, predisposing the patients to osteoporosis and pathological fractures at adulthood. Objective: This study aims at characterizing the vitamin D status and bone health biomarkers in a well-characterized cohort of cALL survivors. Results: Food frequency questionnaires reveal that (i) the total vitamin D intake varies greatly (44–2132 IU/d), (ii) only 16.8% of the participants consume vitamin D supplements, and (iii) 74% of survivors' intakes are below the Recommended Daily Intakes (400 IU/d). For the 42 participants taking vitamin D supplements, the median (2.5–97.5 %iles ) intake is 600 IU/d (21.2–1972 IU/d). Sixteen participants are vitamin D deficient (<30 nM) and 66 insufficient (≥30 – <50 nM). Serum 24, 25(OH)2 D3 concentrations are directly related to those of 25OHD3, and those of 3-epi-25OHD3 below the Lower Limit of Quantification in most samples. The participants' serum concentrations of cross-linked C-telopeptide of type-I collagen and intact amino-terminal pro-peptide of type-I collagen decrease steadily with age, leveling at adulthood, and are at all times higher in males. Conclusion: The present study shows that the prevalence of vitamin D insufficiency or deficiency is not greater in cALL survivors compared to the general Canadian population despite low vitamin D food and supplement intakes. Furthermore, there seem to be no overt imbalance in the gender- and age-adjusted serum bone turnover marker concentrations. Highlights: Majority of cALL survivors have low vitamin D food and supplement intakes. The serum 25OHD3 status of cALL survivors is comparable to the Canadian population. cAll survivors show no overt imbalance in serum bone turnover marker concentrations.