Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C2, by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis. Issue 15 (11th April 2019)

• Record Type: Journal Article
• Authors: Jiang, Yulu; Lu, Shan; Hirai, Go; Kato, Taira; Onaka, Hiroyasu; Kakeya, Hideaki
• Is Part Of: Tetrahedron letters. Volume 60:Issue 15(2019)
• Page Start: 1072
• Page End: 1074
• Publication Date: 2019-04-11
• Subjects: Combined-culture -- Saccharothriolides -- Saccharothrix sp. -- Tsukamurella pulmonis; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.03.034
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Combined-culture method was applied to rare actinomycete Saccharothrix sp. A1506. The production of saccharothriolides was enhanced. A new derivative of saccharothriolides, saccharothriolide C2 was obtained. Abstract: A combined-culture method was applied to saccharothriolide-producing strain Saccharothrix sp. A1506 with the mycolic acid-containing bacterium (MACB) Tsukamurella pulmonis TP-B0596. The combined-culture not only enhanced saccharothriolide production, but also produced saccharothriolide C2, a new C-2 epimer of saccharothriolide C, thereby indicating its potential for increasing the chemical diversity of microbial metabolites.