Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981. (July 2018)

• Record Type: Journal Article
• Authors: Fukasawa, Wataru; Mori, Natsuki; Iwatsuki, Masato; Hokari, Rei; Ishiyama, Aki; Nakajima, Moe; Ouchi, Takahito; Nonaka, Kenichi; Kojima, Hiroki; Matsuo, Hirotaka; Ōmura, Satoshi; Shiomi, Kazuro
• Is Part Of: Journal of antibiotics. Volume 71:Number 7(2018:Jul.)
• Page Start: 682
• Page End: 684
• Publication Date: 2018-07
• Subjects: Antibiotics -- Periodicals; 615.329
• DOI: 10.1038/s41429-018-0041-3
• Languages: English
• ISSNs: 0021-8820

Abstract

Abstract A new dipeptide, named tolyprolinol, was isolated from the static culture of a fungus, Tolypocladium sp. FKI-7981. The structure of tolyprolinol was elucidated asN- acetyl-l -phenylalanyl-l -prolinol. It showed moderate antimalarial activity but did not show cytotoxicity or any other antimicrobial property.