Cystargamide B, a cyclic lipodepsipeptide with protease inhibitory activity from Streptomyces sp. (July 2018)

• Record Type: Journal Article
• Authors: Kitani, Shigeru; Yoshida, Mitsuki; Boonlucksanawong, Ousana; Panbangred, Watanalai; Anuegoonpipat, Atchareeya; Kurosu, Takeshi; Ikuta, Kazuyoshi; Igarashi, Yasuhiro; Nihira, Takuya
• Is Part Of: Journal of antibiotics. Volume 71:Number 7(2018:Jul.)
• Page Start: 662
• Page End: 666
• Publication Date: 2018-07
• Subjects: Antibiotics -- Periodicals; 615.329
• DOI: 10.1038/s41429-018-0044-0
• Languages: English
• ISSNs: 0021-8820

Abstract

Abstract We identified a new cyclic lipodepsipeptide, cystargamide B (1 ), from the mycelial extract of aKaempferia galanga rhizome-derived actinomycete strain, Streptomyces sp. PB013. The planar structure was elucidated based on high resolution fast-atom bombardment mass spectrometry (HRFABMS) spectroscopy and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic data. The absolute configurations of the constituent amino acids were determined using advanced Marfey's method. Cystargamide B (1 ) includes rare structural units: a 5-hydroxytryptophan residue and a 2, 3-epoxy fatty acid side chain. Notably, cystargamide B (1 ) inhibited the protease activity of the NS2B/NS3 complex from dengue virus.