A new protein tyrosine phosphatase 1B inhibitory α-pyrone-type polyketide from Okinawan plant-associated Aspergillus sp. TMPU1623. (August 2018)
- Record Type:
- Journal Article
- Title:
- A new protein tyrosine phosphatase 1B inhibitory α-pyrone-type polyketide from Okinawan plant-associated Aspergillus sp. TMPU1623. (August 2018)
- Main Title:
- A new protein tyrosine phosphatase 1B inhibitory α-pyrone-type polyketide from Okinawan plant-associated Aspergillus sp. TMPU1623
- Authors:
- Yamazaki, Hiroyuki
Takahashi, Kenta
Iwakura, Natsuki
Abe, Tatsuki
Akaishi, Masanari
Chiba, Satomi
Namikoshi, Michio
Uchida, Ryuji - Abstract:
- Abstract A new polyenyl-α-pyrone polyketide, aspopyrone A (1 ), was isolated from a culture broth of Okinawan plant-associatedAspergillus sp. TMPU1623 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of1 was assigned based on NMR experiments. Compound1 exhibited protein tyrosine phosphatase (PTP) 1B and T-cell PTP (TCPTP) inhibitory activities with IC50 values of 6.7 and 6.0 μM, respectively.
- Is Part Of:
- Journal of antibiotics. Volume 71:Number 8(2018:Aug.)
- Journal:
- Journal of antibiotics
- Issue:
- Volume 71:Number 8(2018:Aug.)
- Issue Display:
- Volume 71, Issue 8 (2018)
- Year:
- 2018
- Volume:
- 71
- Issue:
- 8
- Issue Sort Value:
- 2018-0071-0008-0000
- Page Start:
- 745
- Page End:
- 748
- Publication Date:
- 2018-08
- Subjects:
- Antibiotics -- Periodicals
615.329 - Journal URLs:
- https://www.nature.com/ja/ ↗
http://www.nature.com/ ↗ - DOI:
- 10.1038/s41429-018-0054-y ↗
- Languages:
- English
- ISSNs:
- 0021-8820
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4937.900000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 9666.xml